Sequencing Guidelines for Single Cell Copy Number Variant Detection

Technical Note, Last Modified on October 8, 2019, Permalink


The Chromium Single Cell CNV Solution provides a comprehensive, scalable solution for revealing genome heterogeneity and understanding clonal evolution. Chromium Single Cell DNA libraries can be sequenced and analyzed using the Cell Ranger DNA software package. This Technical Note provides guidelines for determining the optimal combination of targeted cell number, sequencing depth, and Copy Number Variation (CNV) resolution for Single Cell DNA libraries.